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Michaël Demarque"Functional consequences of the activity-dependent specification of serotonin (5-HT) in the Xenopus Laevis brain."

Abstract :


Genetic programs, environmental factors and electrical activity interact to drive the maturation of the brain.
Although the cascade of transcription factors that leads to specification of the serotonergic phenotype has been well characterized, its interactions with electrical activity are not known.
I will present data showing that spontaneous calcium spike activity in the hindbrain of developing X. laevis larvae modulates the specification of serotonergic neurons via regulation of expression of the Lmx1b transcription factor. Activity acts downstream of Nkx2.2 but upstream of Lmx1b, leading to regulation of the serotonergic phenotype. The results link activity-dependent regulation of a transcription factor to transmitter specification and functional consequences since changes in the number of serotonergic neurons change larval swimming behavior.

Selected publications

Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior.Demarque M, Spitzer NC.Neuron. 2010 Jul 29;67(2):321-34.

A noncanonical release of GABA and glutamate modulates neuronal migration.Manent JB, Demarque M, Jorquera I, Pellegrino C, Ben-Ari Y, Aniksztejn L, Represa A.J Neurosci. 2005 May 11;25(19):4755-65.

Laurent Groc (IINS)