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Martha Bosma"Pacemaker role of serotonergic neurons in driving spontaneous activity in the developing mouse hindbrain"

Abstract :

Spontaneous activity in the vertebrate brain has been shown to play crucial roles in circuit formation.
In the mouse hindbrain, spontaneous activity is expressed during a discrete window of early embryonic development, and is driven by a specific subgroup of serotonergic neurons. These neurons change properties both over developmental time, and with modulation by maternal drug exposure.

Selected publications

Moruzzi AM, Abedini NC, Hansen MA, Olson JE, Bosma MM (2009). Differential expression of membrane conductances underlies spontaneous event initiation by rostral midline neurons in the embryonic mouse hindbrain. Journal of Physiology 587(Pt 21), 5081-5093.
Rockhill W, Kirkman JL, Bosma MM (2009). Spontaneous activity in the developing mouse midbrain driven by an external pacemaker. Developmental Neurobiology 69(11), 689-704.
Hughes SM, Easton CR, Bosma MM (2009). Properties and mechanisms of spontaneous activity in the embryonic chick hindbrain. Developmental Neurobiology 69(8), 477-490.

Pascal Branchereau de l'INCIA