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Geoffrey T Swanson"Modulation of kainate receptor targeting and function by auxiliary and chaperone proteins "

Abstract :


The functional properties and neuronal localization of ionotropic glutamate receptors are impacted by a variety of auxiliary proteins, interacting or chaperone proteins, and intracellular signaling pathways.
  Our research focuses on systems that alter kainate receptors, a family of ionotropic glutamate receptors that predominantly control neuronal excitability in the CNS. A number of component domains within the receptor subunits serve as target sites for interactions with other proteins.  These include the auxiliary proteins NETO1 and NETO2, the 4.1 cytoskeletal adaptor proteins, and secreted N-glycan-binding lectins. To differing degrees, these proteins shape kainate receptor function and synaptic localization and are therefore relevant to understanding essential aspects of neuronal kainate receptor activity.

Selected publications

IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes.
Gao C, Frausto SF, Guedea AL, Tronson NC, Jovasevic V, Leaderbrand K, Corcoran KA, Guzmán YF, Swanson GT, Radulovic J.
J Neurosci. 2011 Jun 8;31(23):8533-42.
Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins.
Copits BA, Robbins JS, Frausto S, Swanson GT.
J Neurosci. 2011 May 18;31(20):7334-40.

Christophe Mulle de l'IINS