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Diego ODDI "Ultrasonic vocalizations as a behavioral marker of altered sociability in mice following genetic and environmental manipulations."

Abstract :


Impairments in sociability/communication in humans may be the outcome of life events occurring in the early developmental stages of the individual
. Infancy represents a temporal window in which genes and environment, as well as the interplay between the two factors, may enhance the vulnerability to mental illness later in life. Impaired social behavior is a trait shared by many neuropsychiatric disorders (social anxiety, autism and depression among others) which may depend on the quality of affiliative behavior established during early social experiences, namely mother-infant interactions. Here, we show that the analysis of ultrasonic vocalizations (USVs) emitted by mice across their lifespan represents a valuable behavioral assay of the social development of the subject, sensitive to both genetic and environmental manipulations. In addition, USVs potentially allow to detect social abnormalities as early as postnatal day one, when other sensori-motor capabilities are largely immature, thus representing a suitable index of altered social behavior phenotypes.

Selected publications

PLoS One. 2011 Apr 8;6(4):e18637.
Unstable maternal environment, separation anxiety, and heightened CO2 sensitivity induced by gene-by-environment interplay.
D'Amato FR, Zanettini C, Lampis V, Coccurello R, Pascucci T, Ventura R, Puglisi-Allegra S, Spatola CA, Pesenti-Gritti P, Oddi D, Moles A, Battaglia M.CNR, Cell Biology and Neurobiology Institute, Roma, Italy.

Susanna Pietropaolo de l'équipe Martine Cador à l'INCIA