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Félix Viana"Pathophysiology of thermosensitive TRP channels: role in pain, dry eye disease and prostate cancer".

Abstract :


In a variant environmental landscape, detection of temperature changes is critical for survival. 
Terminals of peripheral sensory neurons, innervating the skin and mucosae, are equipped with the molecular machinery responsible for transforming physical (temperature, pressure) and chemical stimuli into trains of action potentials.  Research over the last decade has revealed the critical role played by Transient Receptor Potential (TRP) channels in this process.  I will present some of our recent work on cold-activated TRP channels (TRPM8 and TRPA1), focusing on their role in tearing, their participation in neuropathic pain and their emerging implication in cell proliferation and cancer.

Selected publications

Madrid R, de la Peña E, Donovan-Rodriguez T, Belmonte C, Viana F. Variable threshold of cold-sensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels. Journal of Neuroscience (2009) 29:3120-3131.

Parra A, Madrid R, Echevarria D, del Olmo S, Morenilla-Palao C, Acosta MC, Gallar J, Dhaka A, Viana F, Belmonte C. Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. Nature Medicine (2010) 16:1396-1399.

Scientific focus :

Posdoctoral Positions:
Department of Physiology and Biophysicas, University of Washington (Seattle), Laboratory of Prof. Bertil Hille, between June 1992 and December 1993. Laboratory of Physiology, Catholic University of Leuven (Belgium), Laboratory of Prof. Bernd Nilius, between January 1994 and March 1997. Institute of Physiology I, University Homburg/Saar (Germany). Laboratory of Prof. Arthur Konnerth, between April 1997 and December 1997.

Previous positions:
Marie Curie Fellowship in the laboratory of Dr. Roberto Gallego. Instituto de Neurociencias UMH-CSIC (Alicante) between January 1998 and December 1998. Principal Investigator at Instituto de Neurociencias UMH-CSIC (Alicante) between January 1999 and June 2001.

Current Position:
Investigador Científico CSIC (Tenured Investigator). Since 2009

Marc Landry & Virginie Dousset