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Yavin Shaham"Context-induced relapse to heroin seeking : behavioral and neuronal mechanism".

Selected publications

Lu L, Wang X, Wu P, Zhao M, Morales M, Harvey BK, Hoffer BJ, Shaham Y (2009) Role of ventral tegmental area GDNF in incubation of cocaine craving. Biological Psychiatry 66:137-145
Pickens CL, Golden SA, Adams-Deutsch T, Nair SG, Shaham Y (2009) Long-lasting incubation of conditioned fear in rats. Biological Psychiatry 65:881-886

Conrad KL, Tseng K, Uejima J, Reimers J, Heng L, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121

Scientific focus :


We use rat models to study the cellular and neuroanatomical mechanisms that underlie relapse to drug and palatable food seeking induced by stressors and drug-associated cues

Neurobiology of Relapse Section
Section Chief: Yavin Shaham,

Shaham group projects:

* Incubation of cocaine and heroin craving (time-dependent increases in cue-induced drug seeking after withdrawal from the drug)
* Incubation of fear (time-dependent increases in cue-induced fear responses after conditioned fear training)
* Relapse to palatable food seeking during dieting
* Context-induced relapse to drug seeking


Yavin Shaham received his M.A. in 1988 from the Hebrew University, Jerusalem, and his Ph.D. in 1992 from the Uniformed Services University of the Health Sciences, Bethesda. His postdoctoral training from 1992 to 1995 was at Concordia University, Montreal, in the laboratory of Jane Stewart. Subsequently, he was an affiliated scientist at the Addiction Research Center, Toronto, and an assistant professor in the Psychology Department at the University of Toronto. He joined NIDA in 1998 as a tenure-track investigator, and he is currently the chief of the Neurobiology of Relapse Section of the Behavioral Neuroscience Branch.

P.V. Piazza