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Mimoun AZZOUZ"Gene therapy for neurodegenerative diseases based on lentiviral vectors."

Abstract :

His seminar will cover
recent findings generated from: 1) multiple gene transfer strategies aimed at improving motor neuron survival in animal models of motor neuron diseases; 2) modelling motor neuron disorders in zebrafish.

Selected publications

Jarraya B, Drouot X, Brouillet E, Condé F, Azzouz M, Kingsman SM, Hantraye P, Mazarakis ND & Palfi S. Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia. Science Translational Medicine, 1(2), P 2ra4 (2009)
Wong LF, Yip PK, Battaglia A, Grist J, Corcoran J, Maden M, Azzouz M, Kingsman SM, Kingsman AJ, Mazarakis ND and McMahon SB. Retinoic acid receptor 2 promotes functional regeneration of sensory axons into the adult rat spinal cord. Nature Neuroscience, 9(2):243-250 (2006).
Ralph GS, Radcliffe PA, Bilsland L, Leroux MA, Greensmith L, Mitrophanous KA, Kingsman SM, Mazarakis ND, & Azzouz M. Silencing of mutant SOD1 using interfering RNA induces long term reversal of ALS in a transgenic mouse model. Nature Medicine, 11(4):429-33 (2005).

Scientific focus :

Mimoun Azzouz is a Professor of Translational Neuroscience at the University of Sheffield and formerly Director of Neurobiology at Oxford BioMedica Ltd. Since his appointment to the Chair of Translational Neuroscience, in 2006, he assembled an excellent research team and has been successful in attracting an array of scientific funding from prestigious national and international funding bodies. His current research in the newly established laboratory is focused on 3 major objectives: 1. develop new viral vector systems for gene therapy into central nervous system. 2. Use of these vectors for in vitro and in vivo modelling and investigate mechanism of cell death in neurodegenerative diseases. 3. Develop novel gene therapeutics for neurodegenerative diseases. His group has a long-standing interest in developing gene therapy approaches for neurodegenerative disease. The team utilises viral based gene transfer systems both for research and gene therapy applications. Such viral systems have included lentiviruses and adeno-associated vectors. His research focuses mainly on developing new therapeutic strategies for motor neuron diseases ALS and SMA.

Abdelhamid Benazzouz