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Joanne NASH "Understanding cellular and molecular changes in synaptic dynamics in the parkinsonian striatum"

Abstract :


Changes in synaptic plasticity within the striatum play a major role in the generation of parkinsonian symptoms, and side effects of L-DOPA, such as dyskinesias.
Re-organisation of molecules and proteins that control neurotransmission within striatal synapses probably underpins these abnormalities in synaptic plasticity. Determination of the key synaptic players responsible for driving such abnormalities will reveal novel therapeutic targets for the treatment of parkinsonian symptoms, and also dyskinesias. Using 6-OHDA-lesioned rodent models of Parkinson’s disease and dyskinesia in combination with patch clamp electrophysiological recordings, biochemical techniques and genetic manipulation, we have found fundamental changes in synaptic function that may underpin the pathological abnormalities responsible for parkinsonian symptoms and L-DOPA-induced dyskinesias.

Selected publications

Development and Validation of a Screening Assay for the Evaluation of Putative Neuroprotective Agents in the Treatment of Parkinson's Disease.Yong-Kee CJ, Salomonczyk D, Nash JE.Neurotox Res. 2010 Apr 2. [Epub ahead of print]

Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses.Nash JE, Appleby VJ, Corrêa SA, Wu H, Fitzjohn SM, Garner CC, Collingridge GL, Molnár E.J Neurochem. 2010 Feb;112(3):677-90. Epub 2009 Nov 6.

Erwan Bézard