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Chris de ZeeuwCreating patterns for cerebellar motor coordination

Abstract :


Neurons in the brain communicate with each other in a digital fashion by evoking or silencing spike activities.
Most theories about information processing in the cerebellum assume that increases and decreases of average spike activities form the main sources of information exchange that will ultimately induce changes in motor behavior. Recent electrophysiological recordings during motor coordination indicate that feedback information from the inferior olive to the cerebellum dominates the phase of Purkinje cell activities and motor performance and that cerebellar interneurons are required for the precise temporal patterns of these activities and consolidation of learned motor behavior. Disturbances in these patterns, either by forcing the spikes to fire out of phase or to fire too regular or too irregular, can lead to serious problems in memory formation and/or neurological diseases. In this lecture I will illustrate how each cell type in the cerebellar network is perfectly designed to contribute to specific temporal patterns of spike activities, how these patterns might contribute to phase control and consolidation of procedural memory formation, which factors can disturb these patterns, and how these disturbances can lead to neurological diseases.

Selected publications

Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells.Belmeguenai A, Hosy E, Bengtsson F, Pedroarena CM, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu MT, Elgersma Y, De Zeeuw CI, Jörntell H, Hansel C.J Neurosci. 2010 Oct 13;30(41):13630-43.

Motor Learning in Children with Neurofibromatosis Type I.Krab LC, de Goede-Bolder A, Aarsen FK, Moll HA, De Zeeuw CI, Elgersma Y, van der Geest JN.Cerebellum. 2010 Oct 7. [Epub ahead of print]PMID: 20927664

Role of the cerebellar cortex in conditioned goal-directed behavior.Burguière E, Arabo A, Jarlier F, De Zeeuw CI, Rondi-Reig L.J Neurosci. 2010 Oct 6;30(40):13265-71.PMID: 20926652 [PubMed - indexed for MEDLINE]Related citations

Eric Hosy