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Symposium Synaptic adaptation & NMDA receptor old story, fresh look!

Abstract :

Second Symposium...
Synaptic adaptation & NMDA receptor : old story, fresh look!
Bordeaux University, 3rd of September 2009


The overarching goal of the Symposia of the Bordeaux Neurosciences Institute is to bring locally a selected set of top researchers on a scientific topic that is of broad interest to the community. There will be 2-3 symposia per year, with each symposium lasting 1 or 2 days. Symposia are open to everyone from Bordeaux and outside, and are free.

Organized by Laurent Groc



Since the discovery of synaptic plasticity, decades ago, amazing progress has been made in our understanding of the molecular and cellular mechanisms of this key process. In particular, the glutamatergic N-methyl-D-aspartate (NMDA) receptor, which is present in excitatory synapses, is known to be important for triggering neuronal connection adaptations, such as learning-related plasticity. Interestingly over the last years, fascinating researches on the NMDAR trafficking, its structure-function, and new role during integration of neuronal communication have shed new lights on this “old” key player. The goal of this Bordeaux IFR symposium is to foster scientific exchanges between worldwide experts of the field and the Bordeaux Neuroscience community which has a strong research interest in the understanding of synaptic and network remodelling. The relative compact format of the symposium will favour discussions in a friendly and open atmosphere. You are all welcome!

Invited speakers

Suzanne Zukin (Albert Einstein College of Medicine, New-York, USA)
Gary Westbrook (Vollum Institute, Portland, USA)
Pierre Paoletti (ENS Paris, France)
Stéphane Oliet (CRI-INSERM Bordeaux, France)
Isabel Perez-Otano (University of Navarra, Pamplona, Spain)
And some young researchers from Bordeaux

Lucie Bard (CNRS, Bordeaux)
Amandine Berthet (CNRS, Bordeaux)
Nelson rebola (CNRS, Bordeaux)
    



INTRODUCTION - Laurent Groc
Session 1 : 13h00 - 15h30
Chair / Daniel Choquet

Suzanne Zukin (Albert Einstein College of Medicine, New-York, USA) Regulation of NMDAR calcium permeability and NMDAR-dependent synaptic plasticity by PKA

Isabel Perez-Otano (University of Navarra, Pamplona, Spain) Non-conventional NMDARs and synapse maturation

Lucie Bard (CNRS, Bordeaux) Dynamic regulation of synaptic NMDA receptors by the interaction with scaffold PDZ proteins


Amandine Berthet (CNRS, Bordeaux) Abnormal sucellular localization of dopamine and
glutamate receptors in L-dopa-induced dyskinesia : evidences and path to therapy


15h30-16h00 Coffee Break
Session 2 / 16h00-18h15
Chair Laurent Groc

Gary Westbrook (Vollum Institute, Portland, USA)
Will the real synaptic NMDA receptor please stand up

Pierre Paoletti (ENS Paris, France)
How clamshell-like domains control NMDA receptor activity

Stéphane Oliet (CRI-INSERM Bordeaux, France)
Respective contribution of endogenous glycine and d-serine to NMDA receptor activity

Nelson Rebola (CNRS, Bordeaux)
Synaptic plasticity of the NMDA signaling at mossy fiber - C