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Zafar BASHIR , Séminaire labelisé INB / Ecole doctorale / AXE Synapse"Mechanisms of synaptic plasticity; what is the relevance for learning and memory?"

Abstract :

There is a widely held belief that mechanisms of synaptic plasticity may hold the key to understanding the cellular and molecular bases of learning and memory.
A great deal of effort has been directed to addressing this hypothesis but the picture is still far from clear.

The perirhinal cortex is essential for visual recognition memory since ablation of or damage to this cortex results in deficits in such memory.
There is much evidence that decreases in perirhinal neuronal function are associated with recognition memory and this has led to speculation that synaptic plasticity such as LTD may be the leading candidate for encoding visual recognition memory. In this presentation I will consider recent work that has addressed mechanisms of synaptic plasticity in the perirhinal cortex and will then provide evidence that mechanisms of LTD are critically involved in visual recognition memory.

Selected publications

Expression of long-term depression underlies visual recognition memory Griffiths et al (2008) Neuron 58, 186-194
Moult PR, Correa SA, Collingridge GL, Fitzjohn SM, Bashir ZI.
Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase: a novel mechanism underlying synaptically-induced metabotropic glutamate receptor-dependent long-term depression in the hippocampus.
J Physiol. 2008 Mar 20; [Epub ahead of print]
PMID: 18356198 [PubMed - as supplied by publisher]

Massey PV, Bashir ZI.
Long-term depression: multiple forms and implications for brain function.
Trends Neurosci. 2007 Apr;30(4):176-84. Epub 2007 Mar 1. Review.
PMID: 17335914 [PubMed - indexed for MEDLINE]

Massey PV, Johnson BE, Moult PR, Auberson YP, Brown MW, Molnar E, Collingridge GL, Bashir ZI.
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
J Neurosci. 2004 Sep 8;24(36):7821-8.