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Yannick Marchalant"Influence du système cannabinoide sur la neuro-inflammation et le vieillissement cérébral"

Abstract :


Chronic neuro-inflammation is thought to play an integral role during the initial stages of the cascade of unfortunate biological changes leading to AD (as well as other neurological disorders such as Parkinson's disease or multiple sclerosis).
The importance of chronic brain inflammation has been corroborated by epidemiological studies showing that the daily use of the NSAID ibuprofen for more than 24 months reduced that risk of developing AD by up to 80%. Moreover Cagnin and co-workers in 2001 measured microglia activation (a reflection of an active inflammatory state of the brain) in normal aged and AD patients and observed an increase in activated microglia during the very early stages of the disease and that those activated cells were found in brain region that latter showed the greater amount of atrophy.
Recently, I have been inspired by promising results obtained from manipulation of the endocannabinoid system on the peripheral nervous system and particularly by the anti-inflammatory potential of agonist of this system. For the past few years, I have been thus exploring the anti-inflammatory activity of the endocannabinoid system during a chronic pathological process and normal aging in rodents. We found out that the endocannabinoid system can be targeted in young and aged animals to counteract neuro-inflammation. The doses needed to produce that anti-inflammatory effect were not psychoactive and did reverse some of the memory impairment observed in aged animals. Overall, those results argue for a better understanding of the manipulation of the endocannabinoid system to control inflammatory process with potential beneficial outcome in normal aging as well as in pathological condition like Alzheimer's or Parkinson's disease.

Selected publications

2008: Marchalant Y., Brothers, H.M., Wenk G.L.: Inflammation and aging: Can endocannabinoids help? . Biomedecine and Pharmacotherapy vol. 64, In press pdf
2008: Marchalant Y., Cerbai F., Brothers H.M., Wenk G.L.: CANNABINOID RECEPTOR STIMULATION IS ANTI-INFLAMMATORY AND IMPROVES MEMORY IN OLD RATS. Neurobiology of aging in press. pdf
2007: Marchalant Y, Rosi S, Wenk GL : ANTI-INFLAMMATORY PROPERTY OF THE CANNABINOID AGONIST WIN-55212-2 IN A RAT MODEL OF CHRONIC BRAIN INFLAMMATION. Neuroscience. 2007 Feb 23;144(4):1516-22. pdf

Agnès Nadjar