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Elsa Fabbretti"Novel modulatory effects of pain receptors P2X3 in sensory neurons."

Abstract :


Pain sensory neurons are highly sensitive to changes in extracellular environment to transduce external stimuli into reversible or persistent alteration of threshold of neuronal response.
In particular, sensory neurons express purinergic P2X3 pain receptors sensitive to variation of extracellular ATP. We explored how the NGF and CGRP, involved in chronic pain states like migraine, modulate P2X3 receptors in trigeminal neurons.
Using molecular biology and electrophysiology approaches we study cellular mechanisms and pathways that can alter P2X3 receptor expression and function, thus contributing to change overall neuronal sensitivity in pain states.

Selected publications

D'Arco M, Giniatullin R, Simonetti M, Fabbro A, Nair A, Nistri A, Fabbretti E.
Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons.
J Neurosci. 2007 Aug 1;27(31):8190-201.
Pangrsic T, Potokar M, Stenovec M, Kreft M, Fabbretti E, Nistri A, Pryazhnikov E, Khiroug L, Giniatullin R, Zorec R.
Exocytotic release of ATP from cultured astrocytes.
J Biol Chem. 2007 Sep 28;282(39):28749-58. Epub 2007 Jul 12.
Fabbretti E, D'Arco M, Fabbro A, Simonetti M, Nistri A, Giniatullin R.
Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide.
J Neurosci. 2006 Jun 7;26(23):6163-71.

Eric Boué-Grabot