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Andrew SharottOscillations in the Healthy and Diseased Basal Ganglia

Abstract :

Many recent studies have indicated that oscillations in the cortex and basal ganglia underlie the pathophysiology of several movement disorders. Here, I will present two studies supporting this view, which utilize local field potential recordings from the 6-OHDA rodent model of Parkinson’s Disease and from dystonic patients undergoing the implantation of electrodes for deep brain stimulation. These studies suggest that beta oscillations correlate with dopamine depletion, while oscillations at lower frequncy, directed from the pallidum to muscle, are a potential pathophysiological mechanism in dystonia, Finally, I will present evidence that fast spiking interneuron’s could be modulators of rhythmic activity in the striatum based on recordings from healthy, anaesthetized rats and discuss how this finding could be important in basal ganglia diseases.