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Michela Matteoli"Synaptic vesicle dynamics in developing neurons: how to build a presynaptic terminal."

Abstract :


Over the past decade, evidence has accumulated indicating that, during development, the construction of synapses might rely on the utilization of preassembled sets of synaptic proteins.
In the seminar I'll discuss evidence pointing to the existence of active vesicle traffic and turnover in developing neurons, which lead to the construction of new synaptic sites. I 'll also describe the molecular mechanisms which lead to the formation of filopodia, the precursors of presynaptic sites, and the regulation of synaptic vesicle redistribution by glutamate receptors localized at the growth cone.

Selected publications

Berghuis P, Rajnicek AM, Morozov YM, Ross RA, Mulder J, Urban GM, Monory K, Marsicano G, Matteoli M, Canty A, Irving AJ, Katona I, Yanagawa Y, Rakic P, Lutz B, Mackie K, Harkany T. "Hardwiring the brain: endocannabinoids shape neuronal connectivity."
Science. 2007 May 25;316(5828):1212-6.
Verderio C, Grumelli C, Raiteri L, Coco S, Paluzzi S, Caccin P, Rossetto O, Bonanno G, Montecucco C, Matteoli M. "Traffic of botulinum toxins A and E in excitatory and inhibitory neurons."
Traffic. 2007 Feb;8(2):142-53.
Verderio C, Rossetto O, Grumelli C, Frassoni C, Montecucco C, Matteoli M. "Entering neurons: botulinum toxins and synaptic vesicle recycling."
EMBO Rep. 2006 Oct;7(10):995-9. Review.

Jean Pierre Mothet