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JO Young - Hwan"To eat more or to eat less ? Neurophysiological analysis of feeding-related neural circuitry in the hypothalamus."

Abstract :


Feeding behavior is one of the most important motivated behaviors and the most potent drive for feeding is its reward nature in humans and mammals.
Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. The hypothalamus is the primary locus for integration of signals that influence energy balance. Amongst the hypothalamic nuclei, the arcuate nucleus (ARC) of the hypothalamus is critical for regulation of feeding behavior and is considered to play a key integrative role between the initial afferent signals from the periphery and CNS responses in the regulation of food intake. In addition, the lateral hypothalamus is essential for regulation of feeding behavior and is considered an important structure for the brain reward circuitry. Of particular interest in this regard is that the altered excitability by nutrient-related hormones and nutrients of hypothalamic neurons is a key control mechanism for natural reward behavior and contributes to the control of food intake.
I examined the electrophysiological basis of both endogenous acetylcholine and endocannabinoid actions at hypothalamic synapses of normal & genetically obese animals and evaluated the neurophysiological action of oleic acid on POMC neuron excitability.

Selected publications

Jo YH, Chen YJ, Chua SC Jr, Talmage DA, Role LW.
Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit.
Neuron. 2005 Dec 22;48(6):1055-66.
Jo YH, Wiedl D, Role LW.
Cholinergic modulation of appetite-related synapses in mouse lateral hypothalamic slice.
J Neurosci. 2005 Nov 30;25(48):11133-44.

Eric Boué-Grabot