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Frank Gunn-Moore"Novel intracellular signalling pathways at the node of Ranvier and for neuronal growth."

Abstract :


Neurofascin and Neuron glial-related cell adhesion molecule (NrCAM)
are two members of the L1 family cell adhesion which are involved in several stages of neuronal development. Their fundamental importance in mammalian neuronal development is highlighted by their constituting 1% of all membrane proteins in mature brains and their involvement in growth cone, node of Ranvier and synapse formation.
Mutations in the cytoplasmic tail have been directly linked to human mental retardation and cancer formation. NrCAM has also been linked to addiction and autism in humans. Knockout mouse studies show phenotypic changes, though redundancy in the L1 family has made the understanding of how NrCAM signals in vivo within the cell difficult.
Therefore little was known concerning how these receptors interact intracellularly. For both receptors, we have identified new intracellular binding partners which are involved in the formation of the node of Ranvier or neuronal growth. Our studies have indicated that these are interactions are part of much larger protein complexes. During these studies we have also identified a new member of the 4.1 super-family which has potential links to other novel signalling pathways and possible cancer formation.

Selected publications

Yao J, Taylor M, Davey F, Ren Y, Aiton J, Coote P, Fang F, Chen JX, Yan SD, Gunn-Moore FJ.
Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model.
Mol Cell Neurosci. 2007 Jun;35(2):377-82.

Nathalie Sans