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David M. Lovinger "Endocannabinoid-Dependent Synaptic Plasticity: From Cellular Release to Voluntary Behavior"

Abstract :


Dr. Lovinger received
a B.A. in Psychology from the University of Arizona in 1981 and a Ph.D. in Psychology from Northwestern University in 1987. At Northwestern, he worked with Dr. Aryeh Routtenberg studying the roles of Protein Kinase C and its substrate, the GAP-43/F1 protein, in hippocampal long-term potentiation. His postdoctoral research at the NIAAA focused on the effects of alcohol on ligand-gated ion channels. In 1991 Dr. Lovinger moved to the Vanderbilt University School of Medicine as an Assistant Professor, where in 1998 he rose to the rank of Professor. At Vanderbilt he was also the Deputy Director for Biomedical Science and the Director of the Neuroscience Core within the Kennedy Center. Dr. Lovinger joined the NIAAA in 2001 as a Senior Investigator and Chief of the Laboratory of Integrative Neuroscience. His laboratory is currently studying the modulation and plasticity of synaptic transmission at corticostriatal synapses and the mechanisms by which abused substances effect synaptic transmission.(©CV and picture courtesy of The NIH website) 

Selected publications

Yin HH, Adermark L, Lovinger DM.
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
Neuropharmacology. 2007 Jun 22; [Epub ahead of print]
Adermark L, Lovinger DM.
Combined activation of L-type Ca2+ channels and synaptic transmission is sufficient to induce striatal long-term depression.
J Neurosci. 2007 Jun 20;27(25):6781-7.
Yin HH, Park BS, Adermark L, Lovinger DM.
Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum.
Eur J Neurosci. 2007 Jun;25(11):3226-32.
Lovinger DM, Homanics GE.
Tonic for what ails us ? high-affinity GABAA receptors and alcohol.
Alcohol. 2007 May;41(3):139-43. Epub 2007 May 23. Review.

Olivier Manzoni