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Alastair HOSIE"Neurosteroid regulation of GABAA receptors."

Abstract :


GABA-A receptors are the major mediators of inhibitory neurotransmission and play a vital role in regulating many aspects of animal behaviour.
The neurosteroids allopregnanolone (ALLOP) and THDOC are extremely potent modulators of GABAaR function and may thus play in important role in regulating neuronal activity. Significantly, production of ALLOP and THDOC is disrupted in several mood disorders including depression, premenstrual dysphoria and panic disorder. We have recently identified binding sites for ALLOP and THDOC on GABAa receptors and are currently using transgenic techniques to investigate the physiological roles of these important modulators of nervous system function.

Selected publications

Hosie AM, Wilkins ME, da Silva HM, Smart TG.
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.
Nature. 2006 Nov 23;444(7118):486-9. Epub 2006 Nov 15.

Monique Vallée