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Richard J. Weinberg" The spine: How can an empty blob process information ?"

Abstract :


Most excitatory synapses
are onto spines, generally thought to be compartments with little or no internal structure. How can the spine contribute to signal processing? Current research studies the complex biochemical signaling pathways that mediate long-term synaptic plasticity. I will argue that a major factor controlling these signaling pathways is physical proximity among the elements. The spine contains an internal cytoskeleton that anchors components of these pathways; moreover, it may modify signaling by regulating the spatial relationships among the various enzymes.

Selected publications

Ding JD, Weinberg RJ.
Localization of soluble guanylyl cyclase in the superficial dorsal horn.
J Comp Neurol. 2006 Apr 20;495(6):668-78.

Racz B, Weinberg RJ.
Spatial organization of cofilin in dendritic spines.
Neuroscience. 2006;138(2):447-56. Epub 2006 Jan 4.

Horton AC, Racz B, Monson EE, Lin AL, Weinberg RJ, Ehlers MD.
Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis.
Neuron. 2005 Dec 8;48(5):757-71. 

Daniel Choquet