Aller au contenuAller au menuAller à la recherche

Patricia Di Ciano "The Persistence of addiction : evidence for multiple mechanisms".

Abstract :

A key component of drug addiction is the compulsive, habitual nature of drug seeking that can be induced by environmental events and can continue for months, or even years, after drug use has stopped. To-date, traditional behavioral and pharmacological therapies have attempted to decrease drug ‘craving’ and seeking by focussing on the ability of Pavlovian stimuli to control drug seeking. It is known that behaviour can be parsed broadly into Pavlovian or Instrumental processes, and this may partly explain why treatment approaches aimed at blocking only Pavlovian processes have not been very successful.

Animal models have demonstrated that drug seeking is highly robust when the animal has control over the presentation of the condtioned stimuli (Instrumental learning). Data will be presented to suggest that this type of drug seeking is both behaviourally and neurally dissociable from drug seeking controlled by Pavlovian stimuli. The findings of these studies suggest that multiple parallel mechanisms may control drug seeking under the control of drug-paired conditioned stimuli.


Selected publications

Vanderschuren, L., Di Ciano, P. and Everitt, B.J.

Differential effects of infusion of dopamine receptor anagonists into various striatal subregions on responding for cocaine under a second-order schedule of reinforcement.

The Journal of Neuroscience, 2005, 25: 8665 – 8670.

Lee, J.L.C., Di Ciano, P., Thomas, K.L. and Everitt, B.J. Disrupting reconsolidation of drug memories reduces cocaine seeking behaviour.

Neuron, 2005, 47:795-801.

Di Ciano, P. & Everitt, B.J.

Neuropsychopharmacology of drug seeking maintained by conditioned reinforcers: Insights from studies with second-order schedules of drug reinforcement. Invited Review.

European Journal of Pharmacology, 2005, 526(1-3): 186-198.

Di Ciano, P. and Everitt, B.J..

Persistence of the ability of conditioned reinforcers to maintain drug-seeking. Neuropharmacology : Frontiers in Addiction Research: Celebrating the 30th Anniversary of the National Institute on Drug Abuse, 2004, Vol 47S1 pp 202-213

Di Ciano, P. and Everitt, B.J.

Direct interactions between the basolateral amygdala and nucleus accumbens core underlie cocaine seeking behavior by rats.

Journal of Neuroscience, 2004, 24(32), 7167-7173.

Pier Vincenzo Piazza