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Matthias Klugmann‘Glucagon-Like-Peptide-1 in the brain: Appetite for protection’

Abstract :


Glucagon-like peptide (GLP-1) is a hormone derived by cleavage of proglucagon in intestinal cells.
In response to food ingestion, binds to its receptor (GLP-1R) on pancreatic ß-cells causing cAMP production, Ca2+-influx, and insulin secretion. Moreover, GLP-1 suppresses food intake by acting on hypothalamic cells in the CNS. GLP-1 and GLP-1R are expressed in many brain regions suggesting roles besides regulating energy metabolism. Indeed, we have found that central GLP-1R activation enhances cognitive functions, and is neuroprotective. We will discuss that GLP-1R signaling is linked to molecular components of the biological clock. This connection might represent a mechanism for GLP-1 mediated plasticity. 

Selected publications

Klugmann, M., Leichtlein, C.B., Klaussner, B.K., Symes, C.W., Brooks, A.I., Young, D. and During, M.J. (2006). A novel role of circadian transcription factor DBP in hippocampal plasticity. Mol. Cell. Neurosci. 31:303-14.
Klugmann, M., Symes, C. W., Leichtlein, C. B., Klaussner, B. K., Dunning, J., Fong, D., During, M. J., Young, D. (2005). AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect memory and seizure activity in adult rats. Mol. Cell. Neurosci. 28:347-60.
During, M. J., Cao L., Zuzga, D. S., Fitzsimons, H. L., Jiao, X., Bland, R. J., Klugmann, M., Banks, W. A., Drucker, D. J., Haile, C. N. (2003). Glucagon-like peptide-1 receptor involvement in learning and neuroprotection. Nat. Med. 9:1173-9

Giovanni Marsicano