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Anne Milasincic Andrews " Serotonin and the Aging Brain"

Abstract :

Dr. Anne M. Andrews' research is focused on the neurochemistry of the brain serotonin system; she explores the role of serotonin and its interactions with other neurotransmitter systems in the modulation of complex behavior.
Dr. Andrews manages a group of students from a variety of backgrounds, including Chemistry, Biochemistry and Molecular Biology, Neuroscience, Physics and Bioengineering. This "Andrews Research Group" studies genetically engineered mice and selective neurotoxicologic agents as models of normative, disease and regenerative processes. The aim of the results is the etiology and the treatment of anxiety disorders, major depressive disorder and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's diseases. 

Selected publications

Counterman AE, D'Onofrio TG, Andrews AM, Weiss PS.
A physical model of axonal damage due to oxidative stress.
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5262-6.

Perez XA, Bianco LE, Andrews AM.

Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: Comparison with chronoamperometry in SERT knockout mice.
J Neurosci Methods. 2006 Jun 30;154(1-2):245-55.

Luellen BA, Szapacs ME, Materese CK, Andrews AM.

The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF.
Neuropharmacology. 2006 Mar;50(3):297-308.

Unger EL, Eve DJ, Perez XA, Reichenbach DK, Xu Y, Lee MK, Andrews AM.

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.
Neurobiol Dis. 2006 Feb;21(2):431-43.

Aline Desmedt