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Terry Robinson"Drugs, neuroplasticity and addiction"

Abstract :


A
fundamental question in addiction research concerns why some susceptible individuals undergo a transition from drug use to addiction. Recent studies suggest that the transition to addiction is due in part to a drug-induced reorganization of brain systems involved in incentive motivational processes (such as the nucleus accumbens) and brain systems involved in decision-making and judgment that usually exert inhibitory control over behavior (such as the prefrontal cortex).

This lecture will focus on some of the long-term neurobehavioral consequences of repeated exposure to drugs of abuse, conditions that promote or retard drug-induced neuroplasticity and the effects of drug-induced changes in mesolimbocortical circuitry for behavior and psychological function.

Selected publications

Crombag HS, Gorny G, Li Y, Kolb B, Robinson TE.
Opposite effects of amphetamine self-administration experience on dendritic spines in the medial and orbital prefrontal cortex.
Cereb Cortex. 2005 Mar;15(3):341-8.
Samaha AN, Robinson TE.
Why does the rapid delivery of drugs to the brain promote addiction?
Trends Pharmacol Sci. 2005 Feb;26(2):82-7.
Li Y, Acerbo MJ, Robinson TE.
The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens.
Eur J Neurosci. 2004 Sep
Robinson TE, Kolb B.
Structural plasticity associated with exposure to drugs of abuse.
Neuropharmacology. 2004;47 Suppl 1:33-46. Review.

P.V. Piazza