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Michael D. Ehlers"Endosomes, Intracellular Sorting, and Plasticity Mechanisms at Glutamatergic Synapses"

Abstract :

he remodeling of synapses is a fundamental mechanism for information storage and processing in the brain. Much of this remodeling involves the transport of proteins to and from the postsynaptic membrane via dendritic trafficking events that remain poorly understood.
Here I will describe research in my laboratory directed at understanding the organelles and mechanisms for protein trafficking and turnover in dendrites.
Our goal is to uncover the relationship of this core cellular machinery to synapse formation and function.
Such mechanisms are crucial for the initial establishment of postsynaptic specializations during synaptogenesis, and for activity-dependent changes in synaptic strength that underlie experience-dependent plasticity. 

Selected publications

Molecular morphogens for dendritic spines. Trends Neurosci 25, 64-67.
Ehlers, M. D. (2003).
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nat Neurosci 6, 231-242.
Ehlers, M. D. (2004).
Deconstructing the axon: Wallerian degeneration and the ubiquitin-proteasome system. Trends Neurosci 27, 3-6.
Ehlers, M. D., and Augustine, G. J. (1999).
Cell signalling. Calmodulin at the channel gate. Nature 399, 105, 107-108.
Horton, A. C., and Ehlers, M. D. (2003).
Neuronal polarity and trafficking. Neuron 40, 277-295.
Horton, A. C., and Ehlers, M. D. (2004).
Secretory trafficking in neuronal dendrites. Nat Cell Biol 6, 585-591.
Mu, Y., Otsuka, T., Horton, A. C., Scott, D. B., and Ehlers, M. D. (2003). Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 40, 581-594.
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., and Ehlers, M. D. (2004).
Recycling endosomes supply AMPA receptors for LTP. Science 305, 1972-1975.
Racz, B., Blanpied, T. A., Ehlers, M. D., and Weinberg, R. J. (2004).
Lateral organization of endocytic machinery in dendritic spines. Nat Neurosci 7, 917-918.
Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., and Wenthold, R. J. (2001).
Molecular determinants of NMDA receptor internalization. Nat Neurosci 4, 794-802.
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., and Ehlers, M. D. (2001).
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 21, 3063-3072.
Scott, D. B., Michailidis, I., Mu, Y., Logothetis, D., and Ehlers, M. D. (2004).
Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals.

Daniel Choquet