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Rodrigo A. Cunha "The role of adenosine in controlling synaptic transmission and affording neuroprotection in noxious brain conditions"

Abstract :

denosine is a nucleoside which is released in a manner proportional to the activity of neurons and in particular high amounts in noxious conditions.
The most abundant adenosine receptors is the inhibitory A1 receptors which refrains excitatory synaptic transmission and hyperpolarizes neurons. It is well established that the activation of A1 receptors affords neuroprotection in noxious conditions such as epilepsy and excitotoxicity and ischemia and chemotoxicity.

However, in chronic noxious conditions, there is adesensitization of A1 receptors and an up-regulation of facilitatory adenosine A2A receptors.
And the blockade of these adenosine A2A receptors refrains synaptic plasticity but also affords a robust neuroprotection in chronic noxious brain conditions.

Christophe Mulle