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Conférence mensuelle - Richard Ransohoff“Macrophages from Monocytes & Microglia: Provenance matters!”

Abstract :

Chemokines: The nexus between immunobiology and neurobiology

Inflammation of the central nervous system (CNS) entails varied levels of activation of resident microglia, macroglia and vascular elements, occasionally culminating in recruitment of hematogenous leukocytes. Thus defined, inflammation accompanies most neurological disorders, including multiple sclerosis (MS), stroke, neoplasia, trauma and HIV-1-associated dementia, as well as Alzheimer’s disease and other primary neurodegenerations. Chemokines comprise a family of peptides that act through G protein-coupled receptors (GPCRs) to regulate leukocyte migration throughout all tissues, in an exquisitely specific and flexible fashion. Initial studies asked how chemokines and chemokine receptors governed inflammatory cell recruitment to the CNS during immune-mediated or virus-induced inflammation. Later, it became clear that constitutive and inducible CNS chemokines signal to resident CNS cells, to support developmental and neurophysiological functions as well as regulating the activation of microglia, and the inflammatory functions of astrocytes. Because GPCRs are drug targets, these results have implications for the understanding and treatment of disease.

Scientific focus :

Biographical Sketch

Richard M. Ransohoff, MD, is Director of the Neuroinflammation Research Center in the Department of Neurosciences of Lerner Research Institute, Cleveland Clinic; Professor of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University; and Staff Neurologist in the Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, Ohio. Dr. Ransohoff graduated with honors from Bard College, Annandale, N.Y., with a BA in literature, and received an MD degree with honors from Case Western Reserve University School of Medicine. He completed residencies in internal medicine at Mt. Sinai Medical Center in Cleveland (board-certified, 1981) and in neurology at Cleveland Clinic (board-certified, 1985). From 1984 until 1989, Dr. Ransohoff was a Postdoctoral Fellow in the laboratory of Dr. Timothy Nilsen in the Department of Molecular Biology and Microbiology at Case Western Reserve University School of Medicine., read more...

Klaus Petry, Agnès Nadjar (agnes.nadjar @ u-bordeaux2.fr)

CONFÉRENCE LABELLISÉES FORMATION DOCTORALE NEUROSCIENCES

Conférence animées par les doctorants
Les étudiants n'ont pas à s'inscrire pour participer à ces conférences. Elles se déroulent en anglais et sont bien entendu ouvertes à tous (à toutes les disciplines même hors neurosciences). Un lunch cloture la conférence (discussion avec l'invité), ll est ouvert sur inscription (4 jours à l'avance auprès de Claire Biard "claire-helene.biard@u-bordeaux2.fr". (Free entrance, registration only if lunch with the speaker)