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Conférence mensuelle - Rob Brownstone Sensorimotor confluence: spinal microcircuits for limb movement

Abstract :

Goal-directed movement requires the integration of feedback from sensory systems into motor circuits. During limb movement, multiple sensory modalities originating throughout the limbs inform motor circuits about the status of the limb such that motor patterns can be adjusted appropriately.

Likewise, motor systems can affect sensory systems, for example by regulating the sensitivity of sensory receptors themselves, or through gating of sensory inputs during a specific motor behavior. But are sensory-motor systems organized in a unidirectional, open loop schema, or alternatively in a bi-directional, closed loop schema in which the microcircuits that route sensory information to motor microcircuits would themselves be under the influence of the same motor microcircuits that they modulate?

In this talk, I will discuss spinal dI3 interneurons, which we have shown mediate a cutaneous-motor feedback loop necessary for paw grasp (Bui et al., 2013). I will also discuss their involvement in intraspinal motor-sensory feedback circuits nested within sensory-motor feedback loops, and discuss potential roles of such an intraspinal, nested closed loop organisation.

Selected publications

The following list of refereed publications is presented accorded to the area of research: spinal cord circuits, stem cells and clinical. The names of trainees under Dr. Rob Brownstone’s direct supervision are underlined.

Spinal cord circuits

Bui TV, Akay T, Loubani O, Hnasko TS, Jessell TM, and Brownstone RM. (2013). Circuits for grasping: spinal dI3 interneurons mediate cutaneous control of motor behavior. Neuron (accepted)
Mitra P and Brownstone RM. (2012) An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse. J Neurophysiol 107: 728–741.
Stuart DG and Brownstone RM. (2011) The beginning of intracellular recording in spinal neurons: facts, reflections, and speculations. Brain Res. 1409:62-92.
Brownstone RM and Stuart DG.  (2011) Whither motoneurons?  Brain Res. 1409:93-103.
Brownstone RM, Krawitz S, and Jordan LM. (2011) Reversal of the late phase of spike frequency adaptation in cat spinal motoneurons during fictive locomotion. J Neurophysiol 105:1045-50.

 Stem cell research
Bretzner F, Gilbert F, Baylis F, and Brownstone RM.  (2011)Target populations for first-in-human embryonic stem cell research in spinal cord injury. Cell Stem Cell 8:468-73.
Yohn DC, Miles GB, Rafuse VF, and Brownstone R M. (2008) Transplanted mouse embryonic stem cell-derived motoneurons form functional motor units and reduce muscle atrophy. Journal of Neuroscience 28(47):12409 –12418.

 

Scientific focus :

Dr. Rob Brownstone is a professor in the Departments of Surgery and Medical Neuroscience at Dalhousie University and a neurosurgeon at the QEII Health Sciences Centre in Halifax, Nova Scotia. As a functional neurosurgeon, he implants deep-brain stimulation devices in people with Parkinson’s disease, tremor, and other movement disorders, and spinal cord stimulators in people with pain syndromes. He also performs surgeries for people with epilepsy. As a scientist, he explores the fundamental nature of the neural circuits that control our ability to move. Read more… (© Dalhousie University)

Agenda

Les conférences mensuelles

La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, met en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de la FBN.
Les doctorants seront chargés de l'organisation. Le jour de la conférence un étudiant présentera le conférencier et animera la discussion. La participation à ces conférences est fortement encouragée pour les étudiants en thèse dans les laboratoires de la fédération.


Les étudiants n'ont pas à s'inscrire pour participer à la conférence.
Ces conférences se dérouleront en anglais, salle de conférence de la Plateforme de Génomique Fonctionnelle, sont bien entendu ouvertes à tous (à toutes les disciplines même hors neurosciences).


Un lunch cloture la conférence, Il est ouvert sur inscription (une semaine à l'avance auprès de Elodie Pénicaud <elodie.penicaud@u-bordeaux.fr>, et il est limité en nombre aux premiers inscrits pour qu'il puisse y avoir une vraie discussion.
La liste des conférences, qui auront lieu tous les premiers vendredi du mois, sera publiée pour l'année. Ces conférences couvrent l'ensemble des disciplines des neurosciences bordelaises (les "axes stratégiques") et sont affichés sur le site Bordeaux Neurosciences et sur celui l'Ecole doctorale, sous la rubrique "Formation doctorale en Neurosciences". Le budget attibué à chaque conférencier sera de 1500 euros maxi.(transports, hôtel et repas)