Aller au contenuAller au menuAller à la recherche

Conférence mensuelle - Erin SchumanLocal Protein Synthesis at Synapses.

Abstract :

An individual neuron in the brain possesses approximately 10,000 synapses, many of which are hundreds of microns away from the cell body, which can process independent streams of information.  During synaptic transmission and plasticity, remodeling of the local proteome occurs via the regulated synthesis of new proteins. I will discuss previous and current studies aimed at understanding how protein synthesis is regulated in neurons. 

Selected publications

Bunse, S., Garg, S., Junek, S., Vogel. D., Ansari, N., Stelzer, E.H.K., and Schuman, E.M. (2013). Role of N-cadherin cis and trans interfaces in the dynamics of adherens junctions in living cells. PLOS ONE, in press.
Epstein, I., Tushev, G., Will, T.J., Vlatkovic, I., Cajigas, I.J., Schuman, E.M. (2013). Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil. Phil. Trans. R. Soc. B 369: 20130137. pdf
Hanus, C.T. and Schuman, E.M. (2013). Proteostasis in dendrites. Nature Reviews Neuroscience 14, 638–648 (2013). pdf
Hinz, F.I., Tushev, G., Aizenberg, M., and Schuman, E.M. (2013). Protein synthesis-dependent associative long-term memory in larval zebrafish. Journal of Neuroscience, 33 (39), 15382-15387. pdf
Hinz, F.I., Dieterich, D.C., and Schuman, E.M. (2013). Teaching old NCATS new tricks: Using non-canonical amino acid tagging to study neuronal plasticity. Current Opinion in Chemical Biology 17(5), 738–746. pdf
Holt, C.E. and Schuman, E.M. (2013). The central dogma decentralized: new perspectives on RNA function and local translation in neurons. Neuron 80 (3), 648-657 (2013) pdf
Schuman, E.M. et al.: In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. In: Nature Neurosci. 13, 2010. pp. 897–905.
Schuman, E.M. et al.: Microfluidic local perfusion chambers for the visualization and manipulation of synapses. In: Neuron 66, 2010. pp. 57–68.
Schuman, E.M. et al.: Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal non-canonical amino acid tagging (BONCAT). In: Proc. Natl. Acad. Sci. 103, 2006. pp. 9482–9487.
Schuman, E.M. et al.: Miniature synaptic transmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis. In: Cell 125, 2006. pp. 785–799.
Bingol, B., Schuman, E.M.: Activity-dependent dynamics and sequestration of the proteasome in dendritic spines. In: Nature 441, 2006. pp. 1144–1148.

Scientific focus :

My research activities focus on synapses, the points of contact and communication between neurons. The ability of synapses to change throughout the lifetime of the animal contributes to the ability to learn and remember. We are interested in how synapses are modified at the cellular and molecular level. We are also interested in how neuronal circuits change when synapses change their properties. We conduct all of our studies in the hippocampus, a structure known to be important for memory in both humans and animals. We use molecular biology, electrophysiology and imaging to address the questions detailed below.

A major focus of the lab concerns the cell biological mechanisms that govern modifications at individual synaptic sites. In particular, we are interested in the idea that dendritic protein synthesis and degradation may contribute to synaptic plasticity. We hypothesize that the protein composition of synapses undergoes continuous remodelling – as a result of local protein synthesis and degradation. The particular patterns of protein synthesis and degradation reflect the history of both the neuron and the synapse. Incoming activity patterns are decoded by the regulated synthesis and degradation of proteins, resulting in a change in synaptic efficacy.

post it...



2004

Professor, Caltech, USA, biology
2005
Visitor in biology, Russ Fernald's lab, Stanford University, CA, USA
2007 – 2009
Option Representative, Department of Biology, Caltech, USA
2008
INSERM-sponsored visiting faculty, Ecole Normale Superieur, Paris, France
Since 2009
Director of the Max Planck Institute for Brain Research, Frankfurt

LES CONFÉRENCES MENSUELLES

La Fédération Bordeaux Neurosciences, en concertation avec l'Ecole Doctorale SVS, met en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de la FBN.
Les doctorants seront chargés de l'organisation. Le jour de la conférence un étudiant présentera le conférencier et animera la discussion. La participation à ces conférences est fortement encouragée pour les étudiants en thèse dans les laboratoires de la fédération.
Les étudiants n'ont pas à s'inscrire pour participer à la conférence.
Ces conférences se dérouleront en anglais, salle de conférence de la Plateforme de Génomique Fonctionnelle, sont bien entendu ouvertes à tous (à toutes les disciplines même hors neurosciences).
Un lunch cloture la conférence, Il est ouvert sur inscription (une semaine à l'avance auprès de Elodie Pénicaud <elodie.penicaud@u-bordeaux.fr>, et il est limité en nombre aux premiers inscrits pour qu'il puisse y avoir une vraie discussion.
La liste des conférences, qui auront lieu tous les premiers vendredi du mois, sera publiée pour l'année. Ces conférences couvrent l'ensemble des disciplines des neurosciences bordelaises (les "axes stratégiques") et sont affichés sur le site Bordeaux Neurosciences et sur celui l'Ecole doctorale, sous la rubrique "Formation doctorale en Neurosciences". Le budget attibué à chaque conférencier sera de 1500 euros maxi.(transports, hôtel et repas)