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Postdoctoral positions at Bordeaux Neurocampus

 On line June 23 / 2017

Postdoc in Cortical Plasticity group — Neurocentre Magendie The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) is seeking to recruit a postdoctoral researcher to join their group in Fall 2017.

We are interested in the function and organization of neocortical circuits and their pathophysiological modification in neurodevelopmental disorders. To address these important questions, we will use a combination of in vitro patch-clamp and two-photon calcium imaging experiments as well as pharmacology to investigate crucial cellular parameters in transgenic mouse models.

The successful candidate will be initially funded for two years with the possibility of extension. Excellence will be a primary criterion for selection, but experience in electrophysiology and calcium imaging are a bonus. The candidate must have a PhD or equivalent qualification in either neuroscience, life sciences, medicine, or physics. The candidate should also have a good level of proficiency in English.

The team is based at the Neurocentre Magendie, an INSERM research institute, and member of the Bordeaux Neurocampus — a centre of excellence for neuroscience research in France. The day-to-day language is English, but support would be provided for learning French if the candidate so wishes.
For further information, please contact as soon as possible: Andreas Frick, andreas.frick@inserm.fr

Please see also http://neurocentre-magendie.fr/recherche/Frick/descriptionTeam.php?lang=en Deadline: 15 July 2017




On line May 11 / 2017

3-years Post-Doc position in Neurophysiology at NutriNeuro Institute (Bordeaux, France)


Project title: Role of dietary omega-3 for the treatment of mood disorders: a novel and targetable mechanism

Project: Our lab has been studying for several years the impact of nutritional omega-3 on brain function. We notably demonstrated that dietary omega-3 deficiency induces strong alterations in the brain endocannabinoid system (Lafourcade et al., 2011; Larrieu et al., 2014; Thomazeau et al., 2016; Bosch-Bouju et al., 2016). The project is in the continuity of this work. Profile: We are seeking a talented and highly motivated postdoctoral candidate to investigate the role of omega-3 in neuronal networks in the context of mood disorders.
The project will involve patch-clamp electrophysiology in brain slices, freely moving electrophysiology and optogenetics and behavioral tests in mice. Knowledge of electrophysiological recordings is needed. The postdoctoral candidate will set-up the available equipment for freely-moving optogenetics and electrophysiological recordings. He/she will perform experiments. He/she will write publications and grants. This project is in collaboration with 2 other teams in France and Canada and the postdoctoral researcher will be the coordinator of the project.

The postdoctoral researcher will be based in the lab of Nutrition and Integrative Neurobiology (NutriNeuro), which is located on the site of the University of Bordeaux, France (www6.bordeaux-aquitaine.inra.fr/nutrineuro). The project is funded by the French Medical Research Foundation (Fondation pour la RechercheMédicale).

APPLICATIONS including a CV, list of publications, motivation letter and 2 letters of reference should be sent to sophie.laye @ inra.fr and clementine.bosch-bouju@inra.fr Starting date: The position is available from the 1st of October 2017 for three years.




Post-doctoral position / on line April /14/ 2017


A post-doctoral position is currently available in the Institute of Cognitive and Integrative Neurosciences of Aquitaine in the team "Organization and Adaptability of Motor Systems", in Bordeaux, France.
Using three different animal model systems (Aplysia, Xenopus and mice) our group studies the neurobiological bases of motor development and of short- and long-term behavioral plasticity at the cellular, neural network and integrated systems levels.
The specific project the candidate will be involved in aims to investigate, using reduced in vitro brainstem slice preparations of the mouse during late phases of embryonic development, the neurobiological mechanisms underlying the functional development of the central neuronal networks that generate rhythmic breathing behavior.
The position is funded by the Fondation pour la Recherche Médicale (FRM) for 3 years, starting no later than 1st of October 2017. We are therefore seeking a highly motivated experimental scientist who must have a PhD degree and a strong background in neuroscience with skills in electrophysiology using patch clamp recordings and calcium imaging. Knowledge in molecular biology and immunohistology would be an additional advantage.

The applicant should also have good team working capabilities, the ability to independently carry out experimental research and good communication skills in spoken and written English. French speaking is not obligatory. Applicants should send their CV to Dr. Thoby-Brisson (muriel.thoby-brisson@u-bordeaux.fr).




Bordeaux, March 2017


Available post-doctoral position in synaptic physiology
We are seeking to recruit as soon as possible a post-doctoral fellow expert in slice electrophysiology and imaging to study AMPA receptor trafficking and synaptic function with innovative molecular and imaging approaches.
The project aims at studying the molecular and mechanistic basis of synaptic plasticity in hippocampal brain slices and in vivo. Building on the past work of the Choquet group demonstrating the key role of AMPA receptor surface trafficking in synaptic function, we have devised a variety of innovative molecular tools to control with a high spatio-temporal resolution various aspects of AMPA receptor traffic. In this project, we will use these optogenetic tools to analyse the specific role of various AMPA receptor trafficking pathways in short and long term synaptic plasticity, both in hippocampal brain slices and in vivo.

We will also use high end imaging approaches to image AMPA receptor traffic in brain slices with unprecedented precision and resolution.
Altogether, this project will shine new light on the molecular mechanism of synaptic plasticity and will be linked to behavioural studies of cognitive functions using the same tools.
The position will be financed by an ERC grant from D. Choquet for 24 months. For this position, we are seeking highly motivated individuals, with a proven track record of success, if possible immediately after their PhD, and in any case no more than four years after their PhD. The projects will be conducted in a stimulating and highly interdisciplinary and international environment in a newly established research building, a part of the Bordeaux neurocampus project (Bordeaux, France).

Please send CV and two references to: Daniel.choquet@u-bordeaux.fr Daniel Choquet



on line January 23 /2017

2-years Post-Doc position in cellular neuroscience at NutriNeuro Institute.

Project : Regulation of microglial activation by omega3: a novel and targetable mechanism in neurodevelopmental disorders (S Layé group)

Using electrophysiology and high resolution imaging and functional connectomics, the project aims at understanding how perinatal nutritional environment influences brain wiring.

This 2-year postdoctoral fellowship is funded by Fondation de France. APPLICATIONS including a CV, motivation letter and 2-3 letters of reference should be sent to sophie.laye @ inra.fr and agnes.nadjar @ u-bordeaux.fr

NUTRINEURO Institute


on line  January /11 /2017

2-year postdoctoral position available in Neuroscience/Biological Psychiatry
Laboratory of Nutrition and Integrative Neurobiology (NutriNeuro)
Bordeaux, France

We are seeking a talented and highly motivated postdoctoral candidate to investigate the influence of inflammatory processes on monoamine metabolism and antidepressant treatment response, in the context of a translational project funded by the French Medical Research Foundation (Fondation pour la Recherche Médicale). The project is multidisciplinary, involving clinical/neuropsychiatric assessments, molecular and cellular biology, and biochemistry.

The postdoctoral researcher will join a multidisciplinary group of researchers and clinicians with expertise in neuroscience, psychobiology and biological psychiatry. He/she will be based in the lab of Nutrition and Integrative Neurobiology (NutriNeuro), which is located on the site of the University of Bordeaux, France (www6.bordeaux-aquitaine.inra.fr/nutrineuro).

Qualifications/experience: The ideal candidate(s) will have a PhD and a strong publication record in relevant scientific disciplines. The postdoctoral fellow is expected to write manuscripts and help with writing grants.

Starting date: The position is available immediately for two years. Latest starting date: April 1st, 2017.

Applications, consisting of cover letter, curriculum vitae, research statement, copy of PhD Degree diploma and 3 letters of reference, should be sent to Dr Lucile Capuron by email (lucile.capuron @ inra.fr).


on line June 30,  2016

2-year postdoctoral position in clinical research PROJECT: NEUROCOGNITIVE IMPACT OF JUVENILE OBESITY LAB: Neuroimagery and human cognition - Aquitaine Institute for Cognitive and Integrative Neuroscience (INCIA), Bordeaux University, CNRS We are seeking a highly motivated postdoctoral candidate who will be in charge of the implementation of new analysis pipelines combining morphometry, fMRI task, dynamic resting-state connectivity, multi-shell diffusion imaging and behavioural data using advanced modelling techniques (multivariate approaches, machine learning, computational models) in lean and obese teenagers. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Gwenaelle Catheline by email: gwenaelle.catheline@u-bordeaux.fr More information at: http://www.incia.u-bordeaux1.fr/spip.php?article346

 2-year postdoctoral position in cellular neuroscience PROJECT: INTERPLAY BETWEEN THE DYNAMIC ORGANIZATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY AT THE SINGLE SYNAPSE LEVEL LAB: D. Choquet team - Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS We aim at analysing the interplay between the dynamic organization of AMPA receptors and synaptic transmission at the single synapse level in primary neuronal cultures and on organotypic slice cultures. Building on the expertise of the Choquet group on super resolution imaging coupled to electrophysiological recordings and calcium imaging, as well as new “intelligent” molecular tools, we aim to perform a detailed analysis of the impact of nanoscale AMPA receptor organization on synaptic transmission and short-term synaptic plasticity. The position will be financed by an ERC grant from D. Choquet. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Daniel Choquet by email: daniel.choquet@u-bordeaux.fr

2-year postdoctoral position in physiology and behavioural neuroscience PROJECT: ROLE OF AMPA RECEPTORS TRAFFICKING IN COGNITIVE FUNCTION LABS: This position will benefit from the “joint venture” of two teams (D. Choquet and Y. Humeau teams) - Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS How perturbing the surface diffusion of AMPA receptors may affect cognitive function? Project includes behavioural testing of mice receiving pharmacological, optogenetic and molecular tools targeting AMPARs mobility. Our main goal is to link specific forms of short term and long term plasticity – that would depend on AMPARs mobility - with specific cognitive abilities. A complementary part of the project is to test for the functionality of neuronal circuits and synaptic function using in vitro slice electrophysiology. The position will be financed by an ERC grant from D. Choquet. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Daniel Choquet and Yann Humeau by email: daniel.choquet@u-bordeaux.fr; yann.humeau@u-bordeaux.fr

 3-year postdoctoral/engineer position in neuroimaging PROJECT: DATABASING OF LARGE NEUROIMAGING COHORTS LAB: Groupe d’Imagerie Neurofonctionnelle (GIN) – Institute of Neurodegenerative Disease (IMN), Bordeaux University, CNRS, CEA 1°) Develop improved methods and dedicated software to reliably and automatically measure individual differences in lateralization for anatomy and resting state intrinsic connectivity. 2°) Apply these methods in large brain imaging datasets (about 10 000 subjects, including the BIL&GIN, BIG, MRI-Share and UK-biobank neuroimaging databases). APPLICATIONS including a CV, motivation letter and 2-3 letters of reference should be sent to Fabrice Crivello by email: fabrice.crivello@u-bordeaux.fr More information: http://www.bordeaux-neurocampus.fr/fr/informations-pratiques/emplois-candidatures/post-doc/postdoc-tzourio-mazoyer-s-group.html

Senior postdoctoral position in behavioural neuroscience and neural circuits PROJECT: EXPERIMENTAL STUDIES ON ADDICTION LAB: NeuroCentre Magendie, Bordeaux University, INSERM We are seeking a talented and highly motivated postdoctoral candidate with knowledge in neurophysiology and experimental psychology. The candidate should be technically competent in in vivo electrophysiology (single unit, LFP), and behavioural tests in rodents (including intravenous self-administration). The candidate should be familiar with the MatLab software. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Véronique Deroche-Gamonet by email: veronique.deroche@inserm.fr

Postdoctoral position in cellular and systems neuroscience / super-resolution microscopy and neurophysiology PROJECT: NANOSCALE IMAGING OF THE STRUCTURE AND MECHANISMS OF BRAIN EXTRACELLULAR SPACE LAB: Synaptic Plasticity and Super-Resolution Microscopy, Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Valentin Nägerl by email: valentin.nagerl@u-bordeaux.fr

 2-year postdoctoral position in cellular neuroscience PROJECT: "SYNPATHY" LAB: The project involves a consortium of five European teams. This position will benefit from the “joint venture” of two teams (O. Thoumine and D. Choquet teams) - Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS Our task aims at understanding the role of MDGAs (MAM domain–containing glycosylphosphatidylinositol anchors), novel regulators of trans-synaptic neurexin-neuroligin adhesion (Pettem et al., JCB 2013), in the dynamic organization of excitatory and inhibitory synapses. The recruited postdoc will examine the impact of manipulating MDGA expression levels on the surface diffusion and nano-scale organization of neurexins, neuroligins, as well as AMPARs and GABA-A receptors at synapses in primary hippocampal neurons and organotypic slices. He/she will take advantage of our long-term expertise in single particle tracking and super resolution imaging of glutamate receptors and synaptic adhesion proteins (Heine et al., Science 2008; Opazo et al. Neuron 2010; Czöndör et al., PNAS 2012; Giannone et al., Cell Reports 2013; Nair et al., J Neurosci 2013; Chamma et al., Nat Comm 2016). Using selective replacement strategies, the candidate will also look at the synaptic trafficking and distribution of MDGAs, including molecules carrying autistic mutations. This 2-year postdoctoral fellowship is funded by an ERA-NET Neuron grant is available. If needed, there will be possibilities to extend this stay by applying to other funding sources. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Olivier Thoumine or Daniel Choquet by email: olivier.thoumine@u-bordeaux.fr; daniel.choquet@u-bordeaux.fr

Postdoctoral position in cellular neuroscience and neural circuits PROJECT: MORPHOFUNCTIONAL CONNECTIVITY AND PLASTICITY IN A MEMORY CIRCUIT LAB: Synaptic circuits of memory (C. Mulle Team) - Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS Using novel 3D tracing methods, brain clearing approaches and functional connectomics, the project deals with the organization of CA3 circuits in relation to episodic memory. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Christophe Mulle by email: christophe.mulle@u-bordeaux.fr

Postdoctoral position in cellular neuroscience PROJECT: TRANS-SYNAPTIC MECHANISMS FOR SYNAPTIC SPECIFICATION IN CONTROL AND EPILEPTIC CONDITIONS LAB: Synaptic circuits of memory (C. Mulle Team) - Interdisciplinary Institute for Neuroscience (IINS), Bordeaux University, CNRS The project combines super-resolution imaging, genetic manipulations and synaptic electrophysiology to decipher the mechanisms underlying the specification of synaptic properties in hippocampal circuits and the pathological formation of aberrant synaptic contacts in models of temporal lobe epilepsy. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Christophe Mulle by email: christophe.mulle@u-bordeaux.fr

Postdoctoral position in behavioural and cellular neuroscience PROJECT: ROLE OF HABENULO-INTERPEDUNCULAR A5A3B4 NICOTINIC RECEPTORS IN ADDICTIVE PROPERTIES OF NICOTINE AND ALCOHOL LAB: Memory Interacting Networks, Drugs and Stress (MINDS) - Aquitaine Institute for Cognitive and Integrative Neuroscience (INCIA), Bordeaux University, CNRS Nicotine interacts with nicotinic acetylcholine receptors constituted of 5 α and β subunits. A single nucleotidic polymorphism on α5 subunit gene α5 (α5-SNP) is associated to an increased risk of tobacco dependence, and could be also linked to alcoholism. To understand how the α5-SNP may increase the risk of nicotine/alcohol abuse, we will study the addictive properties of these drugs using mouse models of self-administration in i) α5-KO mice; ii) α5-SNP KI mice or iii) α5-KO in which the WT or mutated version (α5-SNP) of the α5 gene will be re-expressed with lentivirus in α5-rich brain regions. We will assess concurrently drug-induced dopamine (DA) neuron activity, mesolimbic DA release, as well as consequences of α5-SNP on addiction-relevant cognitive traits (anxiety, impulsivity, social stress) before drug taking. Finally, the role α5*AChRs of the habenulo-interpeduncular pathway in the reward/aversion balance will be investigated using optogenetic stimulation. APPLICATIONS including a CV, motivation letter, a copy of PhD Degree diploma and 2-3 letters of reference should be sent to Vincent David by email: vincent.david@u-bordeaux.fr