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Thèse Maria Szlapczynska

Long-Range Connectivity Defines Learning-Induced Intrinsic Plasticity of Prelimbic Neurons

Le 13 juin 2014

Etudiante PhD  dans le laboratoire d'Andreas Frick , Neurocentre Magendie
Soutenance le 13 Juin 2014   , 9h30  ,  Lieu :  Salle de thèses, Bâtiment ED Université  de Bordeaux  Site Carreire .


The medial prefrontal cortex (mPFC) is necessary for the formation of contextual representations and memory expression following fear conditioning.
Recent studies have shown learning-dependent changes in the intrinsic excitability of mPFC neurons. It is not clear, however, whether these changes are region-wide or neuron-type specific. The specific connectivity and intrinsic properties of different neuronal types could cause certain neuronal populations to be preferentially involved in information processing in a learning paradigm. In this project, we investigated this hypothesis by studying the plasticity of intrinsic excitability in the prelimbic (PL) part of the mPFC in two defined neuronal groups: those projecting to the ipsilateral amygdala and those projecting to the contralateral mPFC. We used contextual fear conditioning together with retrograde tracing and whole-cell electrophysiological recordings of labeled pyramidal neurons in adult 2-3 month old male C56BL/6J mice. We show that neurons projecting to the amygdala display learning-dependent changes in neuronal excitability following contextual fear conditioning. In contrast, the excitability of neurons projecting to the contralateral mPFC does not differ between trained and control animals. Together, these results indicate that learning-induced changes in intrinsic excitability are not generalised across all PL neurons but instead are defined by the neurons’ long-range projection targets. 

Contact: Andreas Frick (andreas.frick @ inserm.fr)
Dernière mise à jour le 12.06.2014

Jury

Dr BONTEMPI Bruno
Bordeaux, France
Chairman
Dr NOLAN, Matthew
Edinburgh, United Kingdom
Reviewer
Prof. BASHIR, Zafar
Bristol, United Kindgom
Reviewer
Dr FRICK, Andreas
Bordeaux, France
PhD supervisor

Directeur de thèse



PhD, Group Leader Neurocentre Magendie, INSERM U862 Group "Circuit and dendritic mechanisms underlying cortical plasticity" Inserm U 862
Neurocentre Magendie 

 
Andreas Frick Team
Cortical plasticity mechanisms in normal and pathological conditions