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Thèse de Renan Campos

Striatum, Dopamine and Automatism in Cocaine Addiction and Relapse: Pharmacological and Behavioral Investigation

Le 18 décembre 2017

Renan Campos a préparé sa thèse à l'INCIA   sous la direction de Dr. Martine Cador (INCIA, UMR5287), dans l'équipe "Addicteam" à Charles Perrens. Le 18 Dec à 14h  Salle de réunion de l'INCIA


 One of the most problematic aspects of addiction is the enduring vulnerability to relapse.
Following repeated use, psychostimulants such as cocaine (COC) induce neuroadaptations within the dopamine (DA) system, including one of its major targets, the striatum. DA acts on D1 and D2 receptors (D1R and D2R) that are segregated into two pathways of striatal medium spiny neurons (MSNs) and act in several aspects of addiction; yet their role in relapse remains unclear. We examined the role of D1R and D2R in the ventral and dorsolateral striatum, using a rodent model of COC relapse. Results showed a double dissociation between the actions of DA receptors in both striatal regions. 

To assess the behavioral nature of relapse, we aimed to model the transition to the eventual automatization believed to underlie drug use. Training under our protocol did not elicit habitual behavior, even after repeated COC exposure.

Finally, we began a preliminary chemogenetic study to tackle the role of the D1R- and D2R-bearing MSNs arising from the NAcc in relapse, as conflation of pharmacological and behavioral assessments can represent a promising approach in the search for the basis of drug addiction and relapse.

Keywords: Dopamine receptors; D1 and D2; Nucleus Accubens, Dorsolateral striatum; Reinstatement; Habit based behavior 

Renan Campos / Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA) UMR 5287 CNRS/Université de Bordeaux - Site Carreire, (rccampos @ u-bordeaux.fr)
Dernière mise à jour le 15.12.2017

Jury

Christelle Baunez
Université d'Aix-Marseille, Rapporteur
Marcello Solinas

Université de Poitiers, Rapporteur
François Georges
Université de Bordeaux, Examinateur
Martine Cador
Université de Bordeaux, Directrice de thèse