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HDR d'Alexandre Favereaux

microRNAs et plasticité neuronale : de la physiologie à la pathologie microRNAs and neuronal plasticity: from physiology to pathology

Le 31 mai 2016

Mardi 31 Mai 2016 à 14h00 / Salle: Amphi 11/ Université Bordeaux Carreire


 Since 2005, my research activity has principally focused on the regulation of neuronal gene expression by microRNAs (miRNAs).
miRNAs are small non-coding RNAs that inhibit protein translation by binding to the 3′ untranslated region (3′ UTR) of target mRNAs. miRNAs are abundant in the brain, with the challenge being to identify their roles and targets in specific neuronal functions.
We first demonstrated that miRNAs are key regulator of gene expression in the context of chronic neuropathic pain, with a tremendous therapeutic potential.
In a second study, we showed that miRNAs are also involved in cancer-related pain mechanisms and that miRNAs can be used as analgesic drugs.
In physiological conditions, miRNAs are also important regulators of synaptic protein expression. We recently showed that miRNAs regulate AMPA receptors expression during synaptic plasticity such as the homeostatic scaling paradigm.
Finally, my new project is based on the hypothesis that, in addition to classical synaptic communication, neurons are able to communicate through the exchange of RNAs shuttled between cells in extracellular vesicles called exosomes.


Publications

Letellier M, Elramah S, Mondin M, Soula A, Penn A, Choquet D, Landry M, Thoumine O, Favereaux A. miR-92a regulates expression of synaptic GluA1-containing AMPA receptors during homeostatic scaling. Nat Neurosci. 2014; 17(8):1040-2.

Elramah S, Landry M, Favereaux A. MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms. Front Cell Neurosci. 2014; 8:31.

Kress M, Hüttenhofer A, Landry M, Kuner R, Favereaux A, Greenberg D, Bednarik J, Heppenstall P, Kronenberg F, Malcangio M, Rittner H, Uceyler N, Trajanoski Z, Mouritzen P, Birklein F, Sommer C, Soreq H. microRNAs in nociceptive circuits as predictors of future clinical applications. Front Mol Neurosci. 2013 Oct 17; 6:33.

Favereaux A, Thoumine O, Bouali-Benazzouz R, Roques V, Papon A, Abdel Salam S, Drutel G, Léger C, Calas A, Nagy F, Landry M. Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO J. 2011; 30(18):3830-41.

Jury

Président
Pr. Alain Trembleau

Rapporteur
Pr. Valérie Fénelon

Rapporteur
Dr. Eric Lingueglia

Rapporteur
Dr Guillaume Van Niel

Examinateur
Dr. Olivier Thoumine

 

 

Alexandre Favereaux,
PhD
Associate Professor

University of Bordeaux
Interdisciplinary Institute for NeuroScience - UMR 5297
Central mechanisms of pain sensitization