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Synaptic Dysfunction in Alzheimer Disease (SyDAD)

SyDAD is a European Training Network sponsored by Marie Sklodowska Curie Actions

Le 22 septembre 2015

Do you want to become a top Alzheimer's Disease researcher of the future ?
Yes ? Apply for SyDAD

Apply now / 
Read more about the ESR Projects and how to apply

SyDAD is a European Training Network sponsored by Marie Sklodowska Curie Actions which will train 15 Early Stage Researchers (PhD students) and perform a collaborative research program to reveal the mechanisms behind synaptic dysfunction in Alzheimer Disease (AD).

For these purposes, we have collected world-leading expertise in AD research and synaptic biology from distinguished academic institutes as well as pharmaceutical companies. ESRs will have access to this expertise, cutting-edge technology, an excellent training programme and international exchanges.

ESR Projects and how to apply
The ESRs will pursue 15 different PhD projects, distributed at six organisations.
The applicants are asked to send separate applications directly to each organisation and to provide a list which SyDAD projects (maximum three) they apply for in a prioritised order.


University of Bordeaux, France (Site-responsible scientist: Prof Christophe Mulle)
ESR 2: Role of APP in presynaptic mechanisms.
ESR 7: Mitochondrial dysfunction in relation to synaptic function in mouse models of Alzheimer’s disease.
ESR 12: Synaptic circuits of memory in mouse models of AD

University of Milano, Italy (Site-responsible scientist: Prof. Monica di Luca)
ESR 1: Linking actin-dependent dendritic spine remodelling and ADAM10 activity in AD: the role of CAP2.
ESR 9: A spine to nucleus signalling pathway in Alzheimer's disease.
ESR 15: Development of cell permeable peptides capable of increasing ADAM10 activity.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
ESR 3: Cascade linking Aß and tau-dependent toxicity to synapse loss.
ESR 4: Loss-of-function genetic screening using CRISPR/Cas9.
ESR 8. Synaptic plasticity and calcium remodeling.
Apply to the projects at DZNE by e-mail to application@dzne.de

Janssen Pharmaceutica NV, Beerse, Belgium

ESR 3: Cascade linking Aß and tau-dependent toxicity to synapse loss.
Apply to the Janssen position here: http://jobs.jnj.com/s/u3z0MT

Axon Neuroscience, Bratislava, Slovakia

ESR 5: Rescue of truncated Tau-mediated synaptic dysfunction in vivo.
Apply to the projects at Axon by e-mail to novak@axon-neuroscience.eu

 WEBSITE SyDAD : http://www.sydad.eu/

About SyDAD

SyDAD is an interdisciplinary PhD programme including an innovative research programme with cutting edge methodology, an excellent training programme, international exchanges and a translational and collaborative orientation.


The aims of SyDAD are:


1. To train 15 Early Stage Researchers to a new generation of researchers with an innovative mind-set and full understanding of the requirements of academia, pharmaceutical companies, the clinics and the societal challenges.

2. To, through a collaborative research programme, elucidate how the different pathways underlying synaptic dysfunction in Alzheimer Disease relate to each other and to identify novel pharmaceutical targets and to elaborate a drug discovery platform for future implementation of the results.



Participating Organisations

SyDAD consists of four academic organisations and two pharmaceutical companies that all will hire PhD students: