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CAJAL course 2016: Nutrition and Brain fonctions

Course directors: Sophie Layé / Richard P Bazinet

Du 19 septembre 2016 au 7 octobre 2016

CAJAL course 2016: "Glial cells in health and disease", November 28th - December 11th

Cajal Course 2016: Brain Prize Hippocampus from Circuits to Cognition / 10th to the 31st of October, 2016,

Public seminars, open to everyone /CAJAL Advanced Neuroscience Training Programme

We are pleased to announce a new CAJAL neuroscience course - Nutrition and Brain functions.

About Nutrition and Brain functions:
The purpose of this advanced course is to bring both nutritional and neuroscience researches together for a 3-week intensive course that will integrate both fields. The advance course will provide key foundational knowledge, as well as hands-on experience and exposure to state-of-the-art methodologies in both fields allowing the early researcher to conceptualize the key questions in the field enabling them to design and defend approaches to solve the questions. While the advanced course will include basic models, a focus will be on the application of results to humans. 

The advanced course will combine theoretical and practical training. Methodological and goal-oriented training will be achieved by guiding the students through hands-on experiments during their stay. In addition, the school will promote interactions between students and internationally renowned scientists via a lecture series to stimulate attendees' discussion on lectures and laboratory experiences as well as stimulating attendees interests in the area. Additional skills will include seminars on publishing and presenting research in the nutritional neuroscience.

Date and Location:
19 Septembre - 7 Octobre 2016 / Bordeaux, France/ Campus Carreire
Course Directors:
Sophie Layé (University of Bordeaux, FR)
Richard P. Bazinet (University of Toronto, CA)

Nutrition and Brain functions, 19 September – 7 October 2016, Bordeaux Neurocampus
Apply here. Deadline: 15 July 2016 (Brussels time, Midnight)

Registration Fee : 3.500 € (includes tuition fee, accommodation and meals) Stipends are available. You can apply for a stipend inside the course general application form.

The course is part of the CAJAL Advanced Neuroscience Training Programme sponsored by FENS and IBRO and hosted at the Bordeaux Neurocampus, France.

Speakers and Practical courses 

Richard BAZINET (Toronto, Canada) What the brain uptake rate of fatty acids tells us about their dietary requirements: Implications for food sources and the environment
Olivier MANZONI (Marseille, France) Food for thoughts 

Frédéric CALON (Québec, Canada) Comparing dietary interventions in animal models of neurodegenerative diseases: cognitive enhancement or disease modification
Sophie LAYE (Bordeaux, France) How does dietary fatty acids influence brain function

SUSANNE LAFLEUR (The Netherlands) The interaction between nutrition and the brain; studies in rodents and men
Dana SMALL (USA) When a calorie is not a calorie: Unravelling the signals driving sugar reward

André MARETTE (Québec, Canada) Targeting the gut microbiome to combat obesity-linked diseases Ron de Kloet (The Netherlands) Glucocorticoids and Brain: from early life to senescence

Daniela COTA (Bordeaux, France) Hypothalamic nutrient sensing in the regulation of energy balance
Amanda SIERRA (Bilbao, Spain) Of ghost neurons and ravenous microglia: coupling between apoptosis and microglial phagocytosis in health and disease

Laurent GAUTRON (Houston, USA) Neural Control of Energy Balance: Translating Circuits to Therapies
Sébastien BOURET (Los Angeles, USA) Developmental programming of appetite

03/10/ 2016
Mathias TSCHÖP (Munich, Germany) Neuroendocrine polypharmacy targeting obesity and diabetes
Ana DOMINGOS (Lisboa, Portugal) Lean on body neurons

04/10/ 2016
Carmen SANDI (Switzerland) The impact of stress and anxiety on behavior and brain metabolism Giovanni Marsicano (Bordeaux, France) Role of mitochondrial CB1 receptor in energy metabolism

06/10/ 2016
John CRYAN (Cork, Ireland) The Gut Microbiome: a Key Regulator of brain Function Across the Lifespan
Aniko KOROSI (The Netherlands) Programming of brain structure and function by early-life stress: a role for nutrition and opportunities for interventions

Practical courses

Project 1 : Cellular and behavioral characterization of the effect of high-fat diet on hippocampal function
Instructors: Guillaume Ferreira (NutriNeuro, Bordeaux, France), Mariano Ruiz-Gayo (Madrid, Spain), Mario Carta (IINS, Bordeaux, France) Technical approaches: in vitro patch clamp, biochemistry (WB), behavior (object location memory) With this project, attendees will learn how to study the effect of diet on memory and neurobiological processes

Project 2 : Deleterious effects on omega-3 deficiency on neurogenesis and related spatial memory. Focus on microglial cells
Instructors: Agnès Nadjar (NutriNeuro, Bordeaux, France), Amanda Sierra (Univ Basquo, Spain), Jorge Vallero (Univ Basquo, Spain) Technical approaches: FACS and cell sorting, RTqPCR on extracted cells, confocal analysis, confocal microscopy, behavior (Morris water maze), transgenic mice With this project, attendees will learn how to study the effect of diet on neuroinflammatory processes and neurogenesis

Project 3 : Macrophage-dependent metabolic alterations in diet-induced obesity
Instructors: Ana Domingo (Gulbenkian Institute, Portugal), Xavier Fioramonti (Dijon, France), Agnès Nadjar (NutriNeuro, Bordeaux, France) Technical approaches: in vivo two-photon microscopy, ELISA, metabolic study (food intake, glucose tolerance test...) With this project, attendees will learn how to study the effect of diet on metabolism and peripheral neuroinflammatory processes

Project 4 : Effect of Docosahexaenoic acid on synaptic transmission and plasticity
Instructors: Clémentine Bosch-Boujut (NutriNeuro, Bordeaux, France), Olivier Manzoni (Marseille, France) Technical approaches: In vivo administration of dietary lipids, electrophysiology (patch-clamp), cellular imaging, pharmacology With this project, attendees will learn how patch-clamp electrophysiology can be used to study the impact of nutrients on brain function at cellular and molecular levels.

Project 5 : Involvement of fat metabolism in CBG-KO mice cognitive impairments
Instructors: Aniko Korosi (Amsterdam, The Netherlands), Marie-Pierre Moisan (NutriNeuro, Bordeaux, France) Technical approaches: immunohistochemistry and stereological quantification, free corticosterone and metabolic evaluation (isotopic dilution, ELISA, RIA), proteomic, behavior (Morris Water Maze) With this project, attendees will learn how study stress reactivity and memory linked to nutrition

Project 6 : Dietary lipids, brain lipid metabolism and dopamine metabolism
Instructors: Richard Bazinet (Toronto, Canada), Sylvie Vancassel (NutriNeuro, Bordeaux, France) Technical approaches: fatty acid gas-chromatography, i.v. injection of a stable isotope, HPLC, microdialysis With this project, attendees will learn how to study the lipid metabolism and monoamine metabolism in the brain

Project 7" Gut leakiness and intestinal neuro-glia interaction : impact on metabolism and food motivation".
Instructors: Laurent Gautron (Houston, USA), Muriel Darnaudéry (NutriNeuro, Bordeaux, France)Technical approaches: Food Motivation (Operant skinner boxes), whole-mount immunohistofluorescence and confocal microscopy of alpha-synuclein and glial markers in the intestines. With this project, attendees will learn how to study the role of dietary imbalance on leaky gut and food motivation.

Project 8 : Optogenetic, dopamine and food motivation
Instructors: Pierre Trifilieff (NutriNeuro, Bordeaux, France), Cyril Herry (NCM, Bordeaux, France) Technical approaches: Food Motivation (Operant skinner boxes), optogenetic, EEG recording With this project, attendees will learn how to study the role of dopaminergic brain circuitry in motivation for food

Project 9 : Dietary pattern, food addiction
Instructors: Susanne Lafleur (The Netherlands), Pierre Trifilieff (NutriNeuro, Bordeaux, France) Technical approaches: behavior (skinner box, food preference, choice, etc), pharmacogenetic (DREADDS) With this project, attendees will learn how to study food preference, choice and motivation and the neurobiological mechanisms underlying these processes

Project 10 : Decision making and nutrition
Instructors: Etienne Coutureau (INCIA, Bordeaux, France), Shauna Parkes (NutriNeuro, Bordeaux, France) Technical approaches: behavior, With this project, attendees will learn how to study the neurobiological processes underlying decision making and how specific nutritional habits influence these processes

Antonella Caminiti /
Dernière mise à jour le 25.08.2016