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Cajal Course 2016: Hippocampus

date and venue: 10th to the 31st of October, 2016, Bordeaux School of Neuroscience

Le 8 juillet 2016


Date and venue: 10th to the 31st of October, 2016, Bordeaux School of Neuroscience
Course Organizers:
Jozsef Csicsvari, Institute of Science and Technology, Austria
Charan Ranganath, UC Davis
Christophe Mulle and Mario Carta, University of Bordeaux
Course FENS Liaison
Menno P. Witter, Norwegian University of Science and Technology.
For whom? PhD students and post-docs. http://www.fens.org/Training/CAJAL-programme/CAJAL-programme/Hippocampus_2016/Application-Form-hippocampus2016/

See in this file  the presentation of speakers and instructors...

Below click on the Schedule to enlarge








Background:
Over the past 50 years, the hippocampus has been one of the most intensely studied areas in the brain, and the field has made major breakthroughs in understanding its anatomical connectivity and function. New technical and scientific advances, in turn, have opened up opportunities for mechanistic investigations of hippocampal function at the level of cells, systems, and cortico-hippocampal networks. The goal of this advanced Cajal Course is to give promising young neuroscientists in-depth exposure to the breadth of research on the hippocampus and to provide hands-on training in state-of-the-art methods used to study hippocampal function. Advanced training of young of neuroscientists in this field will nurture talent to build the next generation of European neuroscientists.
Course content:  with state-of-the-art techniques Each morning, students will attend lectures and keynote addresses by leading experts on hippocampal anatomy, physiology, and function. At the circuit level, the course will cover the anatomical and physiological properties of the hippocampus, and the connectivity of cortico-hippocampal networks with a special focus on the plasticity and oscillations in these circuits and the role of inhibitory interneurons in circuit function. At the systems level, the course will cover behavioural and electrophysiological research in rodents concerning the functional role of the hippocampus in spatial navigation and in memory.
Finally, the course will describe the role of the hippocampus in human cognition, based on functional imaging approaches and studies of hippocampal dysfunction in amnesia and in neurological and psychiatric disorders. In the afternoon, students will conduct supervised, week-long research projects to give them direct experience with state-of-the-art research methods, including in vivo and in vitro patch clamp recordings, optogenetic approaches and cellular imaging, new methods for connectivity tracing, recordings and analysis of multichannel unit and local field potential data in behaving animals, and structural and functional MRI and intracranial electroencephalography in humans.


Course layout:
students are in the lead, supported by international experts This advanced course will consist of both didactic lectures and hands-on training. Each morning (9-11AM), students (20 max) will attend keynote lectures and theoretical and methodology courses by leading scientists from the faculty speakers. In the afternoon, students will then spend the rest of the day in the Bordeaux Neurocampus Training Lab for hands-on research training with an expert instructor. Each student will perform two projects during the duration of the course, each lasting for 9 days. Students will work in pairs, allowing them to get close supervision from their assigned Instructors. The training laboratory is fully dedicated to the course and equipped with a wet lab for in vivo electrophysiology setups, five patch-clamp set-ups, with two combined with life cell imaging and calcium imaging and computers for all analyses. In addition, the core facilities of the University, the Bordeaux Imaging Center is available for this course. Students will work closely with expert instructors during the research projects and they will have ample opportunities for informal discussion, consultation, and social interaction with course faculty and visiting lecturers. Several extracurricular activities are planned in between the program, such as panel discussions, outreach activities and social events.

Keynote lectures:
Keynote lectures will be provided by 13 world-renown experts, followed with discussions with the students.

speaker

theme

Peter Jonas

Plasticity and synaptic transmission in the hippocampus (IST, Austria)

Jozsef Csicsvari

Mnemonic coding in hippocampal cell assemblies (IST, Austrai)

Christophe Mulle

Plasticity and synaptic transmission in the hippocampus (University of Bordeaux)

Hannah Monyer

Genetic approaches to study of hippocampal circuit function (University of Heidelberg)

Emrah Duzel

Hippocampal function in neurodegenerative disease (UCL)

Menno Witter

Connectivity of the hippocampus circuits (Norvegian University)

Kim Graham

Role of Hippocampus in human spatial cognition (Cardiff University)

Rosa Cossart

In vivo 2P imaging mechanisms of place-related activity (Aix-Marseille University)

Charan Ranganath

Mnemonic role of hippocampus in Humans and Animals (University of California)

Howard Eichenbaum

Mnemonic coding in hippocampal cell assemblies (Boston University)

Tamas Freund

Interneuron circuits and their function (Institute of Experimental Medecine HAS in Budapest)

Gyorgy Buzsaki

Network oscillation and temporal coding in hippocampus (NYU School of Medecine)

 

TOPICS
Hippocampal neuroanatomy 
Structure and function of cortico-hippocampal networks 
Place-related coding in the hippocampal formation 
Hippocampal interneuron circuits and their function
Role of Hippocampus in human spatial cognition 
Mnemonic role of hippocampus in humans and animals 
Intracellular mechanisms of place-related activity
Network oscillation and temporal coding in hippocampus
Plasticity and synaptic transmission in the hippocampus
Genetic approaches to study of hippocampal function
Hippocampal function in neurodegenerative disease
Modulation of hippocampal function by stress and emotion
Reactivation of recent experiences in the hippocampus during sleep and awake rest
Hippocampal encoding of temporal context 


METHODOLOGY FOR RESEARCH PROJECTS:
In vivo extracellular recordings in behaving animals
In vivo juxtacellular recordings in behaving animals
In vivo optogenetics
Functional Magnetic Resonance Imaging (MRI) and Structural MRI data collection and analysis Analysis of Electroencephalography (EEG) and Local Field Potential (LFP) data
In vivo and in vitro patch clamp recoding
In vivo and in vitro cellular imaging Biophysical modeling
Microconnectomics
Analysis of cell assembly activity
Behavioural methods for hippocampal function in rodents.




INSTRUCTORS AND MINIPROJECTS

 

First block of experiments

 

 

Neuromodulation of hippocampal circuits  - optogenetics, in vivo ensemble and single cell recordings (patch-clamp, juxtacellular)

Marilena Griguoli

(Cherubini’s lab)

 

Ashley Kees

(Mulle’s lab)

 

 

European Brain Research Institute, Rome,

Italy

 

University of Bordeaux, France

 

Cellular mechanisms of oscillation, slice recordings.

Nikolaus Maier

(Schmitz’s lab)

Charite University, Berlin, Germany

Hippocampal connectivity microconnectomics, brain clearing, ultramicroscopy.

Andreas Frick

University of Bordeaux, France

Adult neurogenesis in DG, memory and learning-induced structural plasticity

Nora Abrous

University of Bordeaux, France

Neurocomputation, biophysical models of neural cells and hippocampal circuits

Sandro Romani

Janelia Research Campus, VA, US

Optogenetics and unit recordings during spatial learning

Peter Baracskai (Csicsvari’s lab)

IST, Vienna, Austria

Human hippocampus morphology

Fabrice Crivello

Pierrick Coupet

University of Bordeaux, France

Hippocampal neuronal ensembles and the time organization of behaviour.

Xavier Leinekugel

Paris

University of Bordeaux, France

Functional MRI: Univariate analysis of hippocampal activity during virtual navigation

Christian Doeller

Radboud University, Nijmegen, Netherlands

Sleep, hippocampal function and memory

Lucia Talamini

University of Amsterdam,

Netherlands

Second block of experiments

 

 

Optogenetics, engrams and behaviour

Michele Pignatelli (Tonegawa lab)

Picower institute, MIT,

US

Dendritic processing, synaptic integration in hippocampus, slice recordings, 2P confocal imaging

Nelson Rebola

 

Judit Makara

University of Bordeaux, France

 

The Institute of Experimental Medicine HAS in Budapest,

Hungary

Head-fixed mice, hippocampal single cell electrophysiological recordings, behaving mouse, anatomical reconstruction.

Andrea Burgalossi

University of Tübingen,

Germany

Neuromodulation of hippocampal circuits  - optogenetics, in vitro and in vivo single cell recordings (patch-clamp, juxtacellular)

Mario Carta

Meryl Malézieux

(Mulle’s lab)

 

University of Bordeaux, France

Mutichannel neuronal oscillation recording

Francesco Battaglia

Radboud University, Nijmegen, Netherlands

 

Functional MRI: multivariate voxel pattern similarity analysis

Maureen Ritchey

Boston College,

US

Functional MRI: functional connectivity analysis and MRI-based segmentation of hippocampal subfields

 

Laura Libby

(Ranganath’s lab)

UC Davis,

US

Functional MRI

Chris Bird

University of Sussex, UK

Functional MRI

 

Lucia Talamini

University of Amsterdam,

Netherlands

Multichannel recordings during complex spatial tasks

Kevin Allen

University of Heidelberg,

Germany

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Antonella Caminiti, antonella.caminiti@u-bordeaux.fr
Dernière mise à jour le 04.11.2016